Wednesday, February 19, 2014

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.

This meta-analysis found that when using high dose NSAIDS, naproxen may be the preferred agent because of a lower risk of vascular complications (myocardial infarction, stroke, vascular death). All high dose NSAIDS approximately doubled the risk of heart failure. Some consider naproxen the preferred agent when long-term high-dose NSAID therapy is used in patients at increased risk of cardiovascular disease (uptodate.com 2014).
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